本培训将详细介绍Fed-batch、Intensified fed-batch、perfusion工艺的开发内容与策略，以及上游工艺放大与工艺表征策略，课程包含大量案例分享，为大家在实际项目工艺开发、放大、表征过程中遇到的实际问题提供解决方案与思路，欢迎各相关单位报名参与。
培训介绍
开班时间：2024年3月18日
培训时间：2024年3月19日-4月30日
培训地点：药视网培训考试系统
培训内容
二、CHO细胞灌流工艺开发
三、CHO细胞培养工艺强化
四、CHO细胞培养工艺放大
五、上游工艺表征
相关文献学习
1、Benchmarking of commercially available CHO cell culture media for antibody production；加深理解培养基筛选的重要性。
2、Understanding the effect of temperature downshift on CHO cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state；加深理解培养温度对工艺的重要性。
3、Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures；加深理解pH对工艺的重要性。
4、Mechanisms driving the lactate switch in Chinese hamster ovary cells；加深理解乳酸代谢转化机制。
5、Feeding Lactate for CHO Cell Culture Processes: Impact on Culture Metabolism and Performance；加深理解乳酸耗尽跟氨升高的关系。
6、Tuning Metabolic Efficiency for Increased Product Yield in High Titer Fed-Batch CHO Cell Culture；乳酸的合理利用。
7、Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study。
8、A Practical Approach in Bioreactor Scale-up and Process Transfer Using a Combination of Constant P/V and vvm as the Criterion。
9、Estimating Cell Specific Oxygen Uptake and Carbon Dioxide Production Rates for Mammalian Cells in Perfusion Culture。
10、Understanding the effect of high gas entrance velocity on Chinese hamster ovary (CHO) cell culture performance and its implications on bioreactor scale‐up and sparger design。
11、Mechanism of Antibody Reduction in Cell Culture Production Processes；加深理解二硫键被还原的机制。
12、Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction；加深理解在细胞培养过程中如何防止二硫键被还原。
13、Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures；加深理解在收获与储存过程中如何防止二硫键被还原。
14、Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes。
15、Larger pore size hollow fiber membranes as a solution to the product retention issue in filtration-based perfusion bioreactors；16、PERFUSION CELL CULTURE PROCESSES FOR BIOPHARMACEUTICALS 第3/4/5章。
17、Optimized process operations reduce product retention and column clogging in ATF-based perfusion cell cultures。
18、Upstream cell culture process characterization and in-process control strategy development at pandemic speed。
19、Application of a Quality by Design Approach to the Cell Culture Process of Monoclonal Antibody Production, Resulting in the Establishment of a Design Space。
20、Defining Process Design Space for Monoclonal Antibody Cell Culture。
21、Upstream cell culture process characterization and in-process control strategy development at pandemic speed。
培训模式
包含约20学时课程+直播答疑+文献学习+每日群内互动
讲师介绍
管 老师 硕士毕业于天津科技大学，发酵工程专业。现为某知名生物医药公司PD工艺开发负责人。拥有丰富的抗体上游工艺开发，优化，放大以及连续流工艺的经验。
费用说明
1、培训原价：1999元/人（含授课费/证书费/发票）
户名：徐州易云企业服务有限公司
开户行：中国工商银行股份有限公司徐州淮东支行
账号：1106020409210313389
（付款请注明“ CHO培训 ”）
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